Interstitial Pneumonitis After Everolimus Therapy for Renal Cell Carcinoma

Abstract

Everolimus is an immunosuppressive agent belonging to the mTOR inhibitors group, used in solid organ transplantation and renal cell carcinomas. The use of inhibitors of the mTOR group in renal carcinomas is associated with many side effects, the potentially most severe being interstitial pneumonitis. A 76-year-old female patient presented with exertional dyspnea, fever and cough. In this report, we discuss a patient with everolimus-induced interstitial pneumonia with a review of the relevant literature.