Analysis of Clinical and Laboratory Findings of Secondary Amyloidosis

Abstract

OBJECTIVE: Our aim was to investigate the clinical and laboratory findings of patients with AAamyloidosis.

MATERIAL and METHODS: Fifty-nine patients with AA-amyloidosis were included in this study. The patients were divided into 2 groups. Group-1 consisted of 23 patients with AA-amyloidosis due to familial mediterranean fever (FMF) and Group-2 consisted of 36 patients with AA-amyloidosis due to etiologies other than FMF. The laboratory and clinical characteristics of all patients were compared between groups.

RESULTS: Of the patients, edema was found in 47 (79.6%), hepatomegaly in 8 (13%), splenomegaly in 9 (14.7%), and hypertension in 21 (35.6%). The median age, systolic/ diastolic blood pressure, serum albumin, total cholesterol, creatinine, and proteinuria values of Group-1 and Group-2 were 29 (16- 73) and 50 (16-76) years (p: 0.001)., 135±12.4 / 73.1±9.2 and 133±13.1 / 72.4±8.9 mmHg (p>0.05), 3.33±0.86 and 2.60±0.92 mg/dl (p:0.04), 238.08±115.68 and 227.77±82.52 mg/dl (p>0.05), 2.51±2.74 and 3.81±3.31 mg/dl (p>0.05), 4.35±3.53 and 5.58±5.10 g/day (p>0.05) respectively. Renal replacement therapy (RRT) was performed in 5 patients in Group-1 and 11 patients in Group-2.

CONCLUSION: The most common cause of AA-amyloidosis in our study was FMF, followed by bronchiectasis and chronic obstructive pulmonary disease. Patients with amyloidosis due to FMF were younger than the patients with amyloidosis due to other etiologies. The need for RRT was similar between the groups.