Gentamicin-Induced Acquired Bartter-Like Syndrome: A Case Report and Review of the Literature

Abstract

Aminoglycosides are a group of antibiotics commonly used in the treatment of serious gram-negative bacterial infections. We report a case of acquired Bartter-like syndrome (ABLS) observed following gentamicin treatment for acute infective exacerbation of chronic lung disease. A 38-year-old male was admitted with sudden-onset, rapid symmetrical flaccid weakness in the proximal lower-extremity muscles. His history was remarkable for an acute infective exacerbation of chronic pulmonary disease 11 days before, treated with intravenous amoxicillin/clavulanic acid and gentamicin. The patient paralyzed due to hypokalemia. He was diagnosed with aminoglycosides-induced ABLS. He was managed with potassium and calcium supplements given intravenously for 1 week, followed by 3 weeks of oral administration for both. ABLS induced by gentamicin has rarely been documented in the literature. Early diagnosis and adequate treatment can ensure a good prognosis.