Review

Vol. 31 No. 3 (2022): Turkish Journal of Nephrology Türk Nefroloji Derneği Dergisi TND Dergisi

Article Sidebar

Full Text PDF
Published: Jul 4, 2022
Keywords:
Chronic kidney disease, mitochondria, muscles

Main Article Content

Abdulmecit Yıldız
Division of Nephrology, Uludağ University, Faculty of Medicine Bursa, Türkiye
Talat Alp Ikizler
Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

The Frailty of Advanced Kidney Disease: The Role of Mitochondria

Main Article Content

Abdulmecit Yıldız
Division of Nephrology, Uludağ University, Faculty of Medicine Bursa, Türkiye
Talat Alp Ikizler
Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

Abstract

Uremic toxins contribute to the impairment of mitochondrial function that subsequently could result in organ failure. Mitochondrial dysfunction also plays an essential role in the pathogenesis of sarcopenia in chronic kidney disease patients. It may be feasible to assess the effect of mitoc hondr ial-t arget ed drugs to treat sarcopenia in patients with chronic kidney disease.



Cite this article as: Yıldız A, İkizler TA. The frailty of advanced kidney disease: The role of mitochondria. Turk J Nephrol. 2022;31(3):190-193.


Article Details