Significance of Serum CRP, SAA and C5a Levels in the Diagnosis and Management of Acute Renal Allograft Rejection

Abstract

Interpretation of the significance of SAA, CRP and C5a levels in the early diagnosis and follow-up of acute rejection has been aimed.

Thirty-nine patients who underwent renal transplantation at the Çukurova University Transplantation Unit between November 2001 and January 2004 were included in the study. The levels of SAA, CPR and C5a were measured before transplantation and during two weeks after transplantation.

In 6 of the 39 patients who underwent renal transplantation acute rejection occured. The outcomes indicated that serum SAA and CRP levels increased 1-2 days prior to acute rejection (p<0.001).

It can be concluded that the use of serial measurements of serum SAA and CRP levels is a valuable and easy method in the early diagnosis and management of acute allograft rejection.