The Relation Between Malnutrition-Inflammation Complex Syndrome and Intravenous Iron Therapy in Hemodialysis Patients

Abstract

Iron therapy was shown to increase oxidative stress (OS), atherosclerosis in hemodialysis (HD) patients. An association was found between malnutrition-inflammation complex syndrome (MICS), OS and atherosclerosis. Possible relation between iron therapy and MICS was evaluated in this study. Components of MICS, anthropometric measures, laboratory parameters, cumulative and mean annual iron doses were examined. Patients (46 M, 35 F) aged 50.2±15.1 years, had undergone maintenance HD for 31.6±12.9 months. Existence of coronary artery disease (r= -0.324; p= 0.003) revealed significant correlation with cumulative iron dose. There was no correlation between cumulative iron dose and MICS components (p>0.05). Triceps skinfold thickness (r= 0.317; p< 0.004) and triglyceride levels (r= 0.245; p=0.028) showed significant correlation with mean annual iron dose. No correlation was found with MICS components (p>0.05). Regarding MICS parameters and anthropometric measures, there was no difference between the 3 groups. Our results revealed no relation between iron administration and components of MICS.