The Comparison of Renal Osteodystrophy Parameters in Diabetic and Nondiabetic Patient with Moderate Renal Failure

Abstract

OBJECTIVE: Renal Osteodystrophy (ROD) is a commonly seen complication of chronic renal failure (CRF). In this study, it was investigated that whether diabetes has an additional deteriorating effect on the ROD parameters in patients with moderate renal failure.

MATERIAL and METHOD: This study was carried out in 60 (30 diabetic and 30 non-diabetic) patients with moderate renal failure. Twenty-six healthy subjects were taken as the control group. As ROD parameters, serum calcium (Ca+2) and phosphorus (P) concentrations and alkaline phosphatase (ALP) activities and parathormone (PTH) concentration were measured.

RESULTS: When the results of the patient group were compared with those of the control group, the mean serum Ca+2 concentration was found lower (p<0.05), the mean serum P, PTH concentration and ALP activity were found higher (p<0.001). There were no significant differences between the nondiabetic and the diabetic patient groups in terms of serum Ca+2, P, PTH concentration and ALP activity (p>0.05).

CONCLUSION: In conclusion, we did not find any significant difference between nondiabetic and diabetic subjects in terms of ROD parameters. Therefore, we speculate that diabetes may not create any risk in patients with moderate renal failure for ROD. However, further prospective and detailed studies comprising more patients also including histological examination are needed for clarifying this situation subject.