The Association between Uric Acid and Vitamin D Levels in Patients with Chronic Kidney Disease

Abstract

OBJECTIVE: Hyperuricemia has been said to decrease vitamin D level. The purpose of this study is to examine whether there is an association between serum uric acid and vitamin D levels in patients with chronic kidney disease.

MATERIAL and METHODS: This study was performed in 35 patients with stage 3-4 chronic kidney disease. Biochemical tests, vitamin D level, 24 hour urine creatinine clearance, and proteinuria were analysed. Systolic and diastolic blood pressure were measured. The statistical analysis was performed using SPSS version 15.0. A P value of less than 0.05 was considered statistically significant.

RESULTS: Serum 1,25(OH)2 D3 and 25(OH)D3 levels were low in 28 patients (80%) and in 24 patients (69%) respectively. Data analysis revealed statistically significant associations between serum uric acid and body mass index, 1,25(OH)2 D3 , creatinine, and phosphorus levels (P=0.04, P=0.03, P=0.01 and P=0.001, respectively).

CONCLUSION: Our study demonstrates that there is a significant negative association between serum uric acid and 1,25(OH)2 D3 levels. However, further studies are needed in a larger number of patients.