Evaluation of Children with IgA Nephropathy According to the Oxford Classification

Abstract

OBJECTIVE: In this study, we aim to evaluate the clinical findings and short term results of our patients with IgAN according to Oxford classification.

MATERIAL and METHODS: The medical records and the renal biopsy findings of 25 patients with IgAN were retrospectively reviewed. According to the pathological findings in Oxford classification, those without obvious disorder were accepted as Group 1 (n=16), and those with obvious disorders were accepted as Group 2 (n=9).These groups were compared for gender, age of onset, age of diagnosis, mean blood pressure and estimated glomerular filtration rate (GFR) at diagnosis and follow-up, proteinuria, clinical presentation and prognosis.

RESULTS: The most common complaint of the patients at presentation was hematuria. The most common histopathological renal finding was the proliferation of mesengial cells in varying degrees. Statistically no significant differences of mean blood pressure, GRF changes, protenuria, clinical findings, and prognosis were detected at presentation and follow-up.

CONCLUSION: We could not show short-term effectiveness to predict clinical and laboratory findings, and prognosis of the patients of Oxford classification in children with IgAN.