Plasma 9-cis,11-trans ve 10-trans, 12-cis Conjugated Linoleic Acid Isomers Levels in Continuous Ambulatory Peritoneal Dialysis Patients

Abstract

OBJECTIVE: Peritoneal dialysis is a renal replacement therapy in patients with end stage renal disease.

Conjugated linoleic acid (CLA) refers to a class of positional and geometric conjugated isomers of the

omega-6 essential fatty acid, linoleic acid. This study aimed to investigate biologically active isomers

of CLA (10-trans, 12-cis CLA and -9-cis,11-trans CLA) and the relationship between these fatty acids

and weight, body mass index (BMI), C-reactive protein (CRP) and parathyroid hormone (PTH) in

continuous ambulatory peritoneal dialysis patients (CAPD) and healthy subjects.

 

MATERIAL and METHODS: This study was performed on 51 (21M, 30F) CAPD patients at least

6 months under dialysis, aged 20-75 years and 45 (25M, 20F) healthy control subjects aged 20-60

years. Plasma 10-trans, 12-cis CLA (t10,c12 CLA) and 9-cis,11-trans CLA (c9,t11 CLA) levels were

measured by GS-MS technique.

 

RESULTS: t10,c12 and c9,t11 isomers of CLA levels of the CAPD patients were as follows: 11.84 ±

5.3 and 8.34 ± 4.4 mg/L respectively. The same parameters of the controls were as follows: 12.88 ±

4.1 and 9.20 ± 4.5 mg/L, respectively. The differences between plasma CLA isomers levels of CAPD patients and control subjects were not signifi cant. Isomers of CLA negatively correlated with serum PTH levels in CAPD patients. However, there

was no signifi cant correlation between plasma isomers of CLA and weight, BMI, CRP in CAPD patients.

 

CONCLUSION: These fi ndings suggest that a CLA-rich diet may help in reducing high levels of parathyroid hormone in the case of good control

of phosphorus in CAPD patients associated with secondary hyperparathyroidism.